Picture red blood cells traveling through the
circulatory system. As blood pulses through this system, the arteries
expand to allow the blood to pass. This happens because the arteries release a molecule which keeps the red blood cells smooth (non-sticky) and signals the arterial walls to expand.
The
signaling molecule produced is nitric oxide. When the arteries don't
expand, circulation is restricted resulting in many adverse symptoms.
Poor circulation is also linked to problems with diabetes and
cardiovascular disease.
By re-establishing nitric oxide production, blood flow is regulated and these symptoms can be eliminated
Nitric Oxide (NO) is a free
radical gas in the body that acts as a powerful regulator of circulation (it is
an endogenous vasodilator) and a neurotransmitter (it helps the processing of
nerve signals as they cross synapses).
The 1998 Nobel Prize for Medicine and/or Physiology was awarded jointly to Robert F. Furchgott, Louis J. Ignarro and Ferid Murad for their Discovery of “Nitric Oxide as a Signaling Molecule in the Cardiovascular System”.
Dr Louis Ignarro stated,
“Nitric oxide deficiency can contribute to nearly every major disease of our
times”.
Science Magazine called
nitric oxide ‘Molecule of the Year’ - approximately 5 years before the Nobel
Prize was awarded.
Dr. Valentin Fuster,
President of the American Heart Association stated, “The discovery of nitric
oxide and its function is one of the most important in the history of
cardiovascular medicine”.
“Nitric oxide is your body’s strongest self-defense against heart attacks and
strokes”, Dr. John Cooke, Director of Vascular Medicine,
There have been close to 15,000 articles published world wide in medical and scientific
journals since 1980 on the benefits of nitric oxide. These health effects
impact conditions including: cardiovascular health, sexual dysfunction,
diabetes, cancer treatment, pulmonary problems, kidney function, brain function
and much more.
L-Arginine as a precursor to NO
L-Arginine is one of the 20 amino acids that make up proteins; it is the only amino acid that generates significant amounts of NO. L-Arginine is released from proteins and small peptides in the small intestine and is then absorbed along with other amino acids into the circulatory system. It is then delivered to each cell in the body. Some of the L-Arginine is metabolized for NO Synthesis and some is used for protein synthesis. NO Synthesis occurs in endothelial cells, these are the small cells that make up capillaries and line every blood vessel and lymph duct in the body. If the enzyme that makes NO and its co-factors are available in adequate amounts L-Arginine is converted to NO.
NO & Diabetes
In diabetic patients,
atherosclerotic disease often occludes a portion of a vessel so that the
endothelial cells are not able to properly absorb L-Arginine. If the
endothelial cell can’t absorb L-Arginine, then NO synthesis will be impaired.
More over, if atherosclerotic disease is present, oxygen delivery to cells is
impaired. This molecular oxygen is one of the cofactors needed by the enzyme to
generate NO from L-Arginine.
When the NO diffuses into the smooth muscle cells
that surround the endothelial lining of blood vessels it causes a biological
chain of events that lead to relaxation of these smooth muscle cells. This
relaxation results in increased blood flow.
Tissues that are deprived of normal circulation (hypoxic) cannot produce as much NO as well-oxygenated tissues. Thus an initial period of hypoxia leads to declines in NO production and reduced blood flow. Over time, this condition escalates. Both circulation and neural function are impaired in Diabetic Patients, particularly if tight glucose control is not maintained. It is no wonder that diabetes creates a condition where kidney, heart, and eye problems become worse and wound healing is progressively impaired.
Dr. Joseph Juliano, author of the books When Diabetes Complicates Your Life: Controlling Diabetes and Related Complications, The Diabetic's Innovative Cookbook: A Positive Approach to Living with Diabetes and The Diabetic Male's Essential Guide to Living Well has benefited greatly using nitric oxide products as well as meticulously following other healthful approaches.
Read his letter to the formulator by CLICKING HERE
For a comprehensive overview on nitric oxide's role in diabetes CLICK HERE
GlucoBalance is a nutritional supplement that was developed to promote healthy
blood flow in individuals with Diabetes, by supporting the production of nitric
oxide. When this gaseous molecule is produced in the body it
results in relaxing the walls of blood vessels. When the body has sufficient nitric oxide - blood vessels remain in an open state and blood flow throughout the body
is enhanced.
GlucoBalance is a proprietary blend of amino acids, herbs, vitamins and minerals,
which are blended together under a proprietary method known as N.P S.
(Neurotransmitter Production Support). The N.P.S. delivery system is designed
to allow relatively small quantities of nutrients to substantially increase
neurotransmitter synthesis via a synergistic effect. It is this synergistic
effect that allows GlucoBalance to deliver the
precursors for NO Synthesis while using very small (milligram) quantities of
L-Arginine, unlike other products that use large amounts of L-Arginine.
(This
is crucial for diabetics since multi-gram quantities of L-Arginine can be
dangerous because of its insulin blocking effects.)
Neurotransmitters can only be
formed in the body from a select number of amino acids and other nutrients.
Additionally, in order for neurotransmitters to be produced, certain nerve
cells must be activated. Unless theses nerve cells are activated, simply
supplying nutrients is insufficient to increase production of
neurotransmitters.
The key to increasing the
amount of the neurotransmitter produced, (nitric oxide), by the body is to
supply the needed nutrients while simultaneously activating the nerve cells
that produce the desired neurotransmitter. This concept forms the basis of the
proprietary formulation strategy known as N.P.S. that is utilized to create new
products.
In order for a
neurotransmitter to be synthesized, two things need to happen. First the
nutrient for the neurotransmitter production (its precursor) must be available.
Second, a neuron must be releasing a neurotransmitter in order to initiate
neurotransmitter production. Triggering release of neurotransmitter activates
cellular intake of its precursor in order to replenish what was released by
increasing neurotransmitter synthesis. This is the key to N.P.S.’s synergistic
actions.
Prior to development of
N.P.S. these results could only be produced by multi-gram quantities of
precursors, or could not be achieved at all. It combines milligram amino acid
dosages and delivers macro-gram effects to increase circulating nitric oxide.
Conclusion
As you can see, nitric oxide is crucial to the health of a diabetic. Nitric oxide also has a wide variety of other effects including killing bacteria and viruses, and improving healing of wounds and ulcers. Stress, aging, injuries, and fighting disease-causing organisms can all deplete the body of nitric oxide. These facts make it critical to support the production of NO.
HemOxy, my absolute #1 choice in nitric oxide supplementation contains the nutrients and molecular building blocks needed to safely increase levels of nitric oxide in the body.
Using a breath analyzer test, nitric oxide production peaks in 17 minutes and is completely gone within an hour with regular multi-gram Arginine supplements. With HemOxy the peak occurs after 35 minutes, is 3 times as high, and it takes up to 3 hours before nitric oxide production ceases.
Nitric oxide: From
Menace To Marvel of The Decade
Nitric oxide Review -
Wolfson Institute for Biomedical Research,
Nitric oxide:
discovery and impact on clinical medicine
The Biology of Kundalini & Nitric Oxide
Brain Function
Study: Nitric Oxide
key to brain “Booting Up”
Cortical feedback to
the thalamus is selectively enhanced by nitric oxide
Gases as biological messengers: nitric oxide and carbon monoxide in the brain
Cancer
Microencapsulated iNOS-expressing cells
cause tumor suppression in mice “Macrophages can kill tumor cells by releasing high levels of nitric oxide
(NO) and related reactive nitrogen species such as nitroxyl and peroxynitrite,
after up-regulation of expression of the inducible nitric oxide synthase gene
(iNOS).”
From body
of article:
“Researchers from the University of
Utah and the National Cancer Institute developed an experimental drug that
reacts with a substance inside cancer cells, releasing nitric oxide to kill the
cells or slow their growth without harming healthy cells.”
Nitric Oxide Is a Factor in the
Stabilization of Hypoxia-Inducible Factor-1
in Cancer: Role of Free Radical
Formation
Nitric oxide and gene expression in cancer
cells
The role of nitric oxide in cancer
Cardiovascular Disease
Nitric oxide
deficiency raises Cardiovascular Disease risk in African Americans
UC Irvine researchers reveal structure of molecule that regulates blood pressure
Spiraling high blood
pressure linked to nitric oxide deficiency
Nitric oxide prevents
blood vessel inflammation
Heart Disease Risk
Factor #1: Nitric Oxide
Nitric oxides
critical role in maintaining Cardiovascular Homeostasis
Cardiovascular
Physiology Studies by Richard E.
Klabunde, Ph.D.
Normal Blood Pressure May Be High Blood Pressure! By William Davis, MD
Diabetes
12 Part Series based on Nitric oxide, its
role in Diabetes, Peripheral Neuropathy and Wound Healing By Thomas
Burke Ph.D
From body
of article:
“Nitric Oxide (NO) and its interrelationship with essential growth
factors is critically involved in the entire continuum of events associated
with wound repair. NO is a powerful stimulator of cell
division (proliferation) and maturation, particularly formation of appropriate
cell receptors (differentiation). NO is a necessary mediator of
neovascularization, i.e., the formation of new and eventually mature blood
vessels (angiogenesis) and lymph ducts to nourish the healing tissues. NO
increases the number of fibroblasts (fibroblastic proliferation) and thereby
enhances collagen formation for the healing wound. Lastly, L-arginine and NO
are necessary for the proper cross-linking of collagen fibers to one another,
via proline, to minimize scarring and maximize the tensile strength of healed
tissue.”
Erectile Dysfunction
The Building Blocks
of Erection: Nitric Oxide…..and more Nitric Oxide
Fertility / Infertility
Nitric Oxide May
Prolong Women's Fertility
The role of nitric oxide in fertility disorders in men
Nitric oxide
increases endocervical secretion at the ovulatory phase in the female
“Uterine cervical mucus is crucial
for reproduction, facilitating sperm transport and survival in certain
mammals. The results suggest that
glandular NO production increases cervical secretion.”
“The results suggest that glandular
NO production is a prerequisite for the autonomic nervous modulation of
cervical secretion in the guinea-pig. This could have implications regarding
fertility and fecundity.”
Nitric oxide and its
role during pregnancy: from ovulation to delivery
“NO-donors may be useful for promoting
fertility, while NO-inhibitors might be used for contraception. In conclusion,
NO-donors and NOS-inhibitors may provide novel, effective, safe, and
inexpensive drugs to regulate and steer various functions in female
reproductive life.”
Role of nitric oxide
in implantation and menstruation
These studies open up new
applications for NO-donating and -inhibiting agents in uterine disorders. NO
donors may be useful in the treatment of dysmenorrheal and for promoting
fertility.
AsAb (antisperm antibody) positive
and NO level abnormal may interfere mutually, to intervent the reproductive
process. ICWM therapy could effectively regulate auto-immunity and endocrine
function, and make the infertile patients obtain satisfactory efficacy.
Sickle Cell
Study points to role of nitric oxide in new treatments for Sickle Cell Anemia
Dr. Jonathan Stamler,
lead researcher at Duke, says, “The latest study shows that a red blood cell
from a sickle cell patient is unable to dilate a blood vessel and the reason
for that is that it is unable to release nitric oxide.”
Nitric Oxide Gas May Treat and Prevent Sickle Cell Crisis
“In eight of the nine sickle cell disease
patients, breathing nitric oxide caused their red cells to give up oxygen less
readily than before”
